Genesis Plus GX is a Sega multi-system emulator originally for the Nintendo GameCube and Nintendo Wii, developed by eke-eke. The author claims the emulator has accurate emulation and 100% compatibility with Sega Mega Drive, Mega-CD, Master System, Game Gear, and SG-1000 games. It also has preliminary Pico emulation. The emulator was originally based off Charles MacDonald’s Genesis Plus 1.2a. For Mega-CD games, ISO + WAV, BIN + CUE and ISO + OGG formats are supported; ISO + MP3 is not supported.

Some versions of the emulator were backported to Windows. Genesis Plus GX is also available for a variety of systems as an emulation core of the libretro gaming API.